The best supplements for Ozempic and GLP-1 users
Medically reviewed by Maya Ellison
Published July 10, 2026· Updated July 10, 2026· 7 min read
On a GLP-1, the supplements worth prioritizing support muscle and fill the gaps low appetite creates: enough protein first, then creatine monohydrate for muscle support with resistance training (Kreider et al., 2017), a basic multivitamin, fiber, fluids, and electrolytes. A large share of GLP-1 weight loss can be lean mass (Wilding et al., 2021), which is why muscle comes first. Here is the plain-English guide, and where Aphia fits. Confirm any additions with your provider.
What your body actually needs on a GLP-1
GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound work by suppressing appetite, which means you eat less, and that is the point. The side effect is that eating less can make it harder to get enough of a few key things: protein, certain vitamins and minerals, fluids, and the raw material your muscles need to stay strong. In the STEP 1 analysis, roughly 39% of the weight lost on semaglutide came from lean mass (Wilding et al., 2021), so muscle support tends to top the list.
This page is a plain-English guide to the supplements that come up most for GLP-1 users, why each one matters, and where creatine fits. A quick note on trust: Aphia is not affiliated with any GLP-1 medication or its maker, and no supplement is a substitute for the food, protein, and medical guidance your plan is built on. Always confirm additions with your healthcare provider.
The supplements that come up most for Ozempic users
- Protein (food first, powder if needed): The single most important input for holding onto muscle during weight loss. Aim to hit your daily target from food; a shake can fill gaps on low-appetite days.
- Creatine monohydrate: The most-studied supplement for supporting lean muscle and strength when paired with resistance training (Kreider et al., 2017). More on this below.
- A daily multivitamin: Eating much less can make it harder to cover micronutrient needs; a basic multi is reasonable insurance.
- Fiber and fluids: Constipation and dehydration are common on GLP-1s; adequate water and fiber help.
- Electrolytes: Useful if you are eating and drinking noticeably less than before.
None of these replace a balanced diet or your medication. They support the gaps that low appetite can create. Your provider or a dietitian can tailor the list to you.
Why creatine is on nearly every GLP-1 list
Of the muscle-supporting supplements, creatine has the deepest evidence base. It helps your muscles rapidly regenerate energy during short, hard efforts, so paired with resistance training it helps you train a little harder and build or hold lean tissue (Kreider et al., 2017; Chilibeck et al., 2017). During rapid weight loss, protecting that lean tissue is exactly the goal. The honest caveat is that there are not yet large trials of creatine specifically in GLP-1 users, so it may help support the muscle-preserving work rather than treat or prevent muscle loss.
The practical hurdle on a GLP-1 is appetite. A big chalky shake is easy to skip when nothing sounds good. Aphia delivers the full clinical 5g in four small strawberry-lemonade chews, no water, no mixing, so the one supplement you most want to stay consistent with is also the easiest to take. Meet the chews: Aphia Creatine Chews.
Related reading: creatine and Ozempic, creatine and tirzepatide (Mounjaro and Zepbound), and creatine and protein.
Aphia is a dietary supplement, not a drug, and is not affiliated with, endorsed by, or sponsored by the makers of Ozempic, Wegovy, Mounjaro, Zepbound, or any GLP-1 medication. All product names are trademarks of their respective owners. Creatine supports muscle and strength when paired with regular resistance training; it is not a treatment for muscle loss and is not a substitute for medical advice or a balanced diet. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always talk with your healthcare provider before starting any supplement, especially while on a prescription medication or if you are pregnant, nursing, or have a medical condition. Individual experiences vary.
The muscle-support one, made easy to take
Of the list, creatine is the one people most want to stay consistent with, and the hardest to face as a shake when appetite is low. Here is the formulation, plainly. Meet the chews: Aphia Creatine Chews.
- A full 5g of creatine monohydrateThe clinically studied daily dose, in the most-researched form.
- An easy-to-take chewNo shaker, no volume to stomach when appetite is low.
- Third-party testedEvery batch checked for potency, purity, and heavy metals.
- ✕A replacement for food or proteinCreatine supports muscle; it does not stand in for a balanced diet.
- ✕StimulantsNothing to add jitters or affect a system your medication manages.
- ✕Proprietary blendsOne ingredient, fully disclosed, at the dose that is studied.
So what should you actually buy?
Start with the free and foundational: hit your protein target and do some resistance training. Those two do the real muscle-preserving work. From there, creatine monohydrate is the highest-evidence add-on, and a basic multivitamin, fiber, and electrolytes cover the gaps low appetite tends to open up.
Keep the framing honest: supplements support the routine, they do not replace food, protein, or your medication, and they do not treat muscle loss. Because you are on a prescription, run your list past your provider or a dietitian before you start.
Supplements for GLP-1 users, answered
What supplements should I take on Ozempic?
The priority is enough protein, ideally from food, to protect muscle during weight loss. Beyond that, creatine monohydrate (for muscle support with resistance training), a basic multivitamin, adequate fiber and fluids, and electrolytes are the ones that come up most for GLP-1 users. None replace your diet or medication, and your provider or a dietitian can tailor the list to you.
Is creatine good for Ozempic users?
Creatine monohydrate is the most-studied supplement for supporting lean muscle and strength when paired with resistance training (Kreider et al., 2017), which is exactly the concern during rapid GLP-1 weight loss. It will not change how your medication works, and there are not yet large trials in GLP-1 users specifically, so it may help support the muscle-preserving routine rather than treat muscle loss. Confirm with your provider first.
How much protein do I need on a GLP-1?
Protein needs do not fall just because appetite does, and getting enough is the single most important thing for keeping muscle during weight loss. Many people aim for a target based on body weight and goals; a dietitian can set the right number for you. On low-appetite days, a protein shake can help you get there when whole food feels like too much.
Can I take these supplements with my GLP-1 medication?
Creatine, protein, a multivitamin, fiber, and electrolytes are generally compatible with GLP-1 therapy, and none have a known interaction with the medications. Still, because you are on a prescription and may have other conditions, tell your healthcare provider what you take so they can keep the full picture, especially if you have any kidney concerns.
What form of creatine is easiest on a GLP-1?
When appetite is suppressed, a large powder shake or a fistful of capsules can be hard to face, so many GLP-1 users prefer a small chew. Aphia delivers the full 5g in four strawberry-lemonade chews with no water or mixing. More on the format in what are creatine chews.
Do supplements stop muscle loss on Ozempic?
No supplement prevents muscle loss on its own. What preserves muscle during weight loss is resistance training plus enough protein; creatine and the rest support that work. Framed honestly, these are tools that may help support muscle, not treatments that prevent or reverse muscle loss.
Are creatine chews safe for women on a GLP-1?
Creatine monohydrate has decades of safety research in healthy adults, which we cover in is creatine safe for women. Because GLP-1 therapy often involves other medications and conditions, clear any new supplement with your healthcare provider first, particularly if you have kidney concerns.
One supplement worth staying consistent with. Made easy.
Aphia Creatine Chews: a full 5g, no stimulants, third-party tested. Four chews a day, no shaker, even when appetite is low.